Hydrogel nanoparticles and nanocomposites for nasal drug/vaccine delivery

Hydrogel nanoparticles and nanocomposites for nasal drug/vaccine delivery

[Source: PubMed.org or ResearchGate]

Sara Salatin 1 2Jaleh Barar 1 3Mohammad Barzegar-Jalali 3Khosro Adibkia 3 4Mitra Alami Milani 2 4Mitra Jelvehgari 5 6

Abstract

Over the past few years, nasal drug delivery has attracted more and more attentions, and been recognized as the most promising alternative route for the systemic medication of drugs limited to intravenous administration. Many experiments in animal models have shown that nanoscale carriers have the ability to enhance the nasal delivery of peptide/protein drugs and vaccines compared to the conventional drug solution formulations. However, the rapid mucociliary clearance of the drug-loaded nanoparticles can cause a reduction in bioavailability percentage after intranasal administration. Thus, research efforts have considerably been directed towards the development of hydrogel nanosystems which have mucoadhesive properties in order to maximize the residence time, and hence increase the period of contact with the nasal mucosa and enhance the drug absorption. It is most certain that the high viscosity of hydrogel-based nanosystems can efficiently offer this mucoadhesive property. This update review discusses the possible benefits of using hydrogel polymer-based nanoparticles and hydrogel nanocomposites for drug/vaccine delivery through the intranasal administration.

Affiliations

  • 1Research Center for Pharmaceutical Nanotechnology, Tabriz University of Medical Science, Tabriz, Iran.
  • 2Student Research Committee, Tabriz University of Medical Science, Tabriz, Iran.
  • 3Department of Pharmaceutics, Faculty of Pharmacy, Tabriz University of Medical Sciences, Mailbox 51664, Tabriz, Iran.
  • 4Drug Applied Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
  • 5Department of Pharmaceutics, Faculty of Pharmacy, Tabriz University of Medical Sciences, Mailbox 51664, Tabriz, Iran. mitra_jelvehgari@yahoo.com.
  • 6Drug Applied Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran. mitra_jelvehgari@yahoo.com.

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